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The findings of effective targets and the identification of target binding molecules are two key points in drug discovery. The complete human genome and their rapid increase in structural and functional information led to new possibilities for diagnosis and therapy of diseases, using genetargeted drugs. Currently, gene-targeted drugs includes groove binders, intercalators, alkylators and cleavage agents and are widely used in cancer, Alzheimer's disease, blood pressure, heart and autoimmune diseases research and therapy. A review on the targeted genes, their interaction molecules and the application on disease therapy is presented. Keywords-gene-targeted drug; G-quadruplex; polyamide

Progress in Research on Small Molecules as Gene-targeted Drugs