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Oridonin, the main pharmacological active substance isolated from Rabdosia Rubescens, has been found to show anti-inflammatory, pro-apoptotic, neurological effects, and excellent anticancer activities. However, the clinical application of oridonin is still limited by its poor solubility. The special electromagnetic field treated water (SEFT water) is served as a kind of high quality drinking water in China. In the present work, the SEFT water was used to test its effects on the anticancer activity of oridonin. And we found that the proliferation inhibition effects of oridonin in EC9706 cells were enhanced in SEFT water dissolved DMEM medium. And the apoptosis induction effects of oridonin in EC9706 cells were also enhanced in SEFT water dissolved DMEM medium, implying that SEFT water could enhance the anticancer effects of oridonin in cancer cells. It was also worth to note that the solubility of oridonin was also enhanced in SEFT water, which might contribute to the enhanced anticancer effects of oridonin in SEFT water dissolved medium for cancer cells.

Anticancer Activity of Oridonin Against Esophageal Cancer Cells Enhanced by Special Electromagnetic Field Treated Water