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Objective: To investigate the molecular mechanism of benign prostatic hyperplasia (BPH) and the characteristics of traditional Chinese medicine in the treatment of BPH. Method: Around bFGF/ERK, TGF-β/Smad pathway and related apoptosis gene expression, By analyzing the expression of TGF-β, bFGF and their respective mRNA, ERK enzyme, Smad protein level, combined with the mechanism of traditional Chinese medicine in the treatment of BPH, to explore the rule of the occurrence of BPH.. Result: Growth factor theory, hormone endocrine theory, apoptosis theory is the main mechanism of prostatic hyperplasia, BFGF/ERK, TGFβ/Smad pathway and related apoptosis gene expression were the most important in growth factor theory, Chinese medicine has obvious advantages in the treatment of BPH. Conclusion: BFGF/ERK,TGF-β/Smad pathway and the expression of related apoptotic genes on the occurrence of BPH, the development of great significance, for the treatment of BPH in traditional Chinese medicine pharmacological research and clinical treatment to provide new ideas and new methods. Benigin prostatic hyperplagia (BPH) is one of the common urinary tract diseases causing urinary dysfunction in elderly men. It has performance of urgency, frequent urination, dysuria and urinary endless and other symptoms. Two necessary conditions for the occurrence of benign prostatic hyperplasia are Relative to the elderly and the body has the function of the existence of the testis [1].Its incidence increased with age,the incidence of 50 years old was 30% ~ 50%,to 80 years of age up to 90% [2].With the accelerated process of China's population aging, the incidence of BPH is increasing year by year, the research and breakthrough for the treatment of BPH is particularly urgent. Molecular Mechanisms of Prostatic Hyperplasia At present, the incidence of BPH theory has the growth factor theory, hormone endocrine theory [4-5], the theory of apoptosis [6-7].The three theories are cross, revealing the characteristics of BPH from different angles. Among them, male and female hormone disorders is the source of BPH;disorder of apoptosis can be induced by the change of growth factors and hormones. And the growth factor is the direct main factor that regulates the prostate hyperplasia, and plays the role of bridge. Growth Factor Theory: Growth factor theory [8-10] thinks that the pathogenesis of BPH is closely related to the 4 kinds of peptide growth factors: Bfgf [3], TGF-β, EGF, IGF-I. In these 4 growth factors,the precise regulation of TGF-β and bFGF is an important mechanism for maintaining the balance of proliferation and apoptosis. And BFGF/ERK and TGFInternational Conference on Biomedical and Biological Engineering (BBE 2016) © 2016. The authors Published by Atlantis Press 153 β/Smad is an important pathway leading to prostate hyperplasia, which can be used to study the molecular mechanism of BPH. TGFβ /Smad Pathway In the TGFβ signal transduction, TGF-β regulates c-myc expression through classical Smads signaling pathway, and regulates cell proliferation [13].I-Smads can be firmly combined with TβRI, so that it can not be Smad2/3 phosphorylation to blocke he signal transduction process, which constitute a negative feedback regulation loop in the TGFβ signal transduction; R-Smads protein is activated by type I receptor activation, and Smad4 protein formation complex, together with the nucleus, where to guide the transcription of the gene.DNA and Smad affinity is relatively low, and need to be combined with other transcription factors to form a stable protein [1112].In addition, the literature indicates that TGF-β can inhibit the transcription of cmyc gene so that the cells stop in the late G1, while bFGF can make c-myc gene activation, antagonistic TGFβ.

Molecular Mechanism of Traditional Chinese Medicine Treatment of BPH based on bFGF/ERK and TGF-a#946; /Smad Pathway