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Black Cumin (Nigella sativa) has long been known to be efficacious in curing diseases. Many studies that prove Black Cumin or better known in the community by the name Black Seed can be efficacious as an immunomodulator, antibacterial, antiinflammatory antioxidant and as an antidiabetic. Black Cumin or better known by the trade name Habbatusauda has been widely circulating in the market, both in the form of dry or oil in drug stores and pharmacies so it is easy to obtain. Some of these Habbatusauda products can be found in a single form or in combination with other oils such as a mixture of Habbatusauda oil with Soursop leaf extract, and in the form of a mixture of Habbatusauda oil with Olive oil. This research is an experimental study with a pretest and post test with control group design. This study used 24 white male Wistar which were divided into 6 groups randomly. Group I as a negative normal group. Group II as a positive control group. Group III was given a single black cumin oil dose of 3.9 mg / 20 gram/day. Group IV was given black cumin oil mixed with soursop leaves at a dose of 3.9 mg / 20 grams/day. Group V was given black cumin oil mixed with olive oil at a dose of 3.9 mg / 20 grams/day. Group VI was given Metformin 65 mg / kg / day. The study was conducted for 11 days where alloxan was injected on the 3rd day. Blood sampling is done on the 2nd, 6th, and 11th day and the glucose levels are examined using the Easy Touch® brand Glucotest. The data obtained were analyzed statistically with One Way Anova and continued with Post Hoc Tests using the SPSS 16.0 for Windows Evaluation Version program. One Way Anova results on decreasing blood glucose levels between treatment groups showed a significant difference with p: 0,000 or p <0.01. Post Hoc Tests results showed a significant difference p: 0,000 or p <0.01 group II with groups III, IV, V, VI. However, there were no significant differences from groups III, IV, V in the decrease in blood glucose levels of p: 0.018 or p> 0.01. From the results of this study it was found that a single black cumin oil, black cumin oil mixed with soursop leaves and olive oil black cumin oil have the same effect in decreasing the blood sugar levels of alloxaninduced male white mice.

Comparison of Antidiabetes Effects of Single Black and Mixed Black Cumin Products on Reduction of Blood Glucose Male White Mice