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The role of Ca2+ release from endoplasmic reticulum (ER) in influencing intracellular Ca2+ oscillation is elucidated. Various types of oscillations in a two-pool model are discussed, based on fast-slow dynamic analysis. Three types of burster are obtained by varying the parameter affecting Ca2+ release from ER, namely, subHopf-subHopf of point-cycle type, subHopf-cycle of point-cycle type with multiple rhythms and fold-fold of pointpoint type. The results may help us better understand the role of Ca2+ release played in complex intraand inter-cellular Ca2+ signaling. Keywords-bifurcation; calcium oscillation; fast-slow dynamic analysis

Simulations to Evaluate the Impact of Ca2+ release from Endoplasmic Reticulum on Intracellular Ca2+ Oscillations