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This work aimed to study the relationship between the mechanisms of the formation of toxic coagulopathy and nephrotoxic effects of molybdenum, as well as the development of a pathogenetically substantiated method for the prevention of chronic toxic coagulopathy and nephropathy using the pineal gland hormone melatonin. A solution of ammonium paramolybdate was administered to Wistar rats for two months at a dose of 50 mg/kg through a tube into the stomach. Against the background of chronic molybdenum intoxication, a solution of melatonin was administered intragastrically at a dose of 5 mg/kg of body weight. Under the conditions of a 6-hour spontaneous diuresis, a study was conducted of the main processes of urination, indicators of the cortico-papillary gradient of the concentration of urea, and sodium in the layers of kidney tissue. We studied the state of the hemostatic system and lipid peroxidation processes after two months of experiments. The experiments showed that the prophylactic administration of melatonin causes a decrease in the severity of pathological changes in the indicators of vascular-platelet and coagulation hemostasis, anticoagulant, fibrinolytic link, a decrease in the level of thrombinemia associated with the restoration of indicators of the osmoregulatory function of the kidneys. Positive effects correlate with the restoration of the level of lipid peroxidation products and the activity of antioxidant blood enzymes. The results of the study allow reasonably recommending the use of the antioxidant melatonin to develop methods for correcting impaired renal function when molybdenum compounds are exposed to the body.

The Effect of Melatonin on the Functional State of the Hemostatic System and Osmoregulatory Kidney Function in Rats With Chronic Molybdenum Intoxication