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Prematurities or low birth weight commonly contributes to the mortality rate of newborns. About 35% of babies born prematurely are very vulnerable for inability to adapt to the extrauterine environment. This condition often requires intensive monitoring such as the Neonatal Intensive Care Unit (NICU) for infant safety. Premature babies who undergo treatment at the NICU generally use breathing aids to support the needs of their physiological conditions. Premature babies who are attached to breathing aids must be in a calm condition so that there is synchronization between the baby's breath with the breathing aids manifested by changes in heart rate, respiration rate, and oxygen saturation. Various therapies are used to provide calming effects such as music therapy. Indonesian people are familiar with reading holy alquran (murottal therapy) as therapy for the sick. This study aims to find out the effect of murottal alquran therapy on changes in baby's physiological parameters: heart rate, respiration rate and oxygen saturation in premature infants with mechanical ventilation.This study used a quasiexperimental pre-post test design for 20 randomly selected infants through a simple random sampling approach, with criteria for infant attachment to mechanical ventilation mode (CPAP), 24-34 weeks' gestation, not experiencing ischemic hypoxic encephalopathy. Data collection was taken by measuring heart rate, respiration rate, and oxygen saturation before and after murottal alquran therapy was given for 3 days. Data were analyzed univariately for each variable looking at the frequency distribution, percentage, and average value, as well as the standard deviation of each variable. To see the difference and the effect of murottal therapy intervention using Wilcoxcon, Mann Whitney, and Friedman test with a significance level of 95% (p <0.05).The results showed that most babies were male (55%), the average gestational age was 3132 weeks, birth weight was 2675, the birth process was sectio caesaria using CPAP mode mechanical ventilation with average PEEP 8, oxygen flow 7.75, Fi02 36.75%. There was a difference in mean values, where before therapy the respiration rate was 47.2 and the heart rate was 126.5 SPO2 95.4 and after 3 days of murottal therapy the respiratory rate was 41.7 and the heart rate was 133 SPO2 97.6. Friedman test results showed the influence of murottal therapy on respiration rate (p = 0.031) and heart rate (p = 0.05) SPO2 (0.01) P <0.05.Murottal Alquran therapy is effective in using premature infants with mechanical ventilation against the hemodynamic stability of the baby during treatment in the NICU.

The Effect of Murottal Alquran Therapy on Heart Rate, Respiration Rate, Saturation Oxygen of Premature Infants Using Mechanical Ventilation in the Neonatal Intensive Care Unit