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Dengue infection control is one of the main priority health programs in Indonesia. Although the vector control has been implemented, the dengue fever outbreak cannot be prevented. Hence, another preventive approach, such as dengue vaccination needs to be carried out. To accelerate towards independency of vaccine seed, the dengue vaccine research and development is conducted in form of consortium for synergized research. Objective: The study aims to identify challenges in the research process of developing dengue vaccine in Indonesia. Methods: The challenges of developing dengue vaccine research for each stage was identified and grouped based on the criteria management and technical challenges. Results: In Indonesia, the dengue vaccine is being developed in a tetravalent recombinant sub unit protein form, utilizing a porcine free (halal) production system and using Indonesia’s virus strains. The development process involves the universities, research institutes, vaccine industry and government. However, this innovative and laboratory based research still faces challenges, in terms of the imported reagent procurement system, less flexible financial scheme, unequal laboratory standard for each member consortium, heavy workload, and also limited experience and knowledge for bioprocess technology. Endeavors have been done to overcome these challenges, specifically, building the trust among the members, having the same vision, sharing the access, facilities, and technology. However, to accelerate vaccine product, sustainable and specific mechanism of finance, secure reagents availability, sufficient infrastructure and staff competency improvement for long-term research are required.

Dengue Vaccine Research Challenges Toward Independency of Vaccine Seed in Indonesia