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This study analysed the wound healing and antioxidant activities of Swietenia macrophylla seed and Syzygium aromaticum bud. The antioxidant activity of Swietenia macrophylla seed and Syzygium aromaticum bud were determined using diphenyl-1picrylhydrazyl (DPPH) scavenging assay. The cytotoxicity activity using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay against human skin fibroblast 1184 cells was used to determine the relative cell viability of the plant extract meanwhile the wound healing activity was determined by analysing the cell migration using the scratch assay. The highest percentage of antioxidant activity was shown by Syzygium aromaticum bud at 79.28% ± 0.04 compared to 22.50% ± 0.00 by Swietenia macrophylla seed. The highest percentage of relative cell viability for Swietenia macrophylla seed oil was observed at the concentration of 0.01 ppm while Syzygium aromaticum bud at 10 ppm. The highest percentage of wound closure observed from the mixture of 0.1 ppm Swietenia macrophylla seed and 10 ppm Syzygium aromaticum bud at 1:1 volume ratio showed the recovery percentage of 44.60% ± 8.42 at 48 hours after treatment. Meanwhile, the wound closure of Swietenia macrophylla seed and Syzygium aromaticum bud were only 35.46% ± 7.34 and 39.49% ± 6.84 respectively. The finding indicates that the mixture of Swietenia macrophylla seed and Syzygium aromaticum bud able to treat wounds better compared to the sole usage of the plant extracts.

Wound Healing and Antioxidant Activities of Swietenia Macrophylla Seed and Syzygium Aromaticum Bud