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Composite hydroxyapatite-collagen-chitosan as bone graft materials for bone fracture has been synthesized using exsitu method. Combining the advantages of hydroxyapatite with chitosan and collagen as composites bone material that it show good biocompatibility and can bond with surrounding host tissues inherent from hydroxyapatite. In this research hydroxyapaptite was synthesized from cow bone with calcination method. The main of this research is to determine the chemical and physics characteristics from the bone graft. The analysis data from Spectra IR indicated vibration of OH, PO4 and CO3 from hydroxyapatite, also –NH2, C=O and C-H from collagen and chitosan along with the peak wave number shifting. The result from SEM characterization was indicated surface morphology formed mineral apatite layer with rough crystal.

Synthesis Hydroxyapatite/Collagen/Chitosan Composite as Bone Graft for Bone Fracture Repair