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Cyanolide A Fig. 1. Structure of Cyanolide A Cyanolide A was demonstrated highly potent molluscicidal agent against the snail vector Biomphalaria glabrata (LC50 = 1.2 μM). Due to its novel biological activity, Cyanolide A is of particular interest for scientists: it could be an effective and selective molluscicide agent that has the potential to eradicate schistosomiasis. As a serious diseases threatened human’s health, it was reported that more than 200 million people in developing countries have been infected, and more than 700 million people are at risk of this disease . Significantly, Cyanolide A was found to be noncytotoxic when tested against H-460 human lung adenocarcinoma and Neuro-2a mouse neuroblastoma cell lines (maximum test concentration of 35 μM). Herein, we described our synthetic strategy towards (±)-Cyanolide A and the present synthetic work of this molecule. Our retrosynthetic analysis of (±)-Cyanolide A (1) is outlined in Scheme 1. International Conference on Advances in Energy, Environment and Chemical Engineering (AEECE-2015)

Synthetic Study towards (p)-Cyanolide A: Synthesis of the Intermediate of (p)-2-(6-ethyl-2-(4-methoxyphenyl)-1, 3-dioxan-4-yl) Acetaldehyde