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A contusion or bruise occurs when blood vessels are damaged or broken because of a trauma to the skin. The initial phase in responding to a contusion in the body is the entry of platelets into the wound area. This platelet infiltration functions as a hemostasis. This study aimed to determine the effectiveness of Wedelia biflora leaf extract against platelets count in rats with contusion. The research used a completely randomized design (CRD). The experimental animals used were 20 of male rats (Rattus novergicus) randomly assigned into four treatment groups namely rats treated with Wedelia leaves extract of 0% (P0, control), 10% (P1), 20% (P2) and 40% (P3) for 8 days. The whole blood was collected on day 1, 5 and 8 and analyzed using an automatic cell counter. The data were analyzed using ANOVA. The results showed a significant influence (p<0.05) of the treatment and time on the platelet count in rats. A significant relationship was also found between the platelets count and contusion area.

The Use of Wedelia biflora Leaf Extract Influences the Platelet Count in Rats with Contusions