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Biochemical changes in blood can be used as an indicator in liver and kidney disorder. This study aims to discover the changes of serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), creatinine and blood urea nitrogen (BUN) levels after the implant of black devil snail shell powder in rabbits. This study used 6 male rabbits, aged 6-8 months and weighted 1.5-2 kg which were divided into 2 groups. Surgical procedure was done sterile and aseptically by creating defect in the left area of femur diaphysis with the size of 0.5 mm and depth reached to canalis medullaris. Group 1 (G1) was not implanted and left to heal on its own, while group 2 (G2) was implanted with 0.25 g of black devil snail shell powder. Blood sample was withdrawn from auricular vein in day 0 before surgery, and day 7, 14, 28, 56 after surgery. The SGOT and SGPT level increased in day 7 after surgery and were significantly different between groups. The BUN level increased in day 14 after surgery, while creatinine increased in day 7 with no significant differences found between groups. The biochemical changes of liver and kidney is still in its normal range, so cue shell powder has the potential to be developed as natural hydroxyapatite.

Biochemical Changes of Liver and KidneyAfter Bone Graft Implant from Black Devil Snail (Faunus ater) Shell Material