English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background& Aims:The correlation between low serum dehydroepiandrosterone sulfate(DHEA-S) levels and coronary artery disease(CAD)is yet unclear. Therefore,we investigated the correlation between DHEA-S levels and the presence or severity of CAD in middle-aged and elderly men. Methods:Fifty-six consecutive middle-aged and elderly men who underwent selective coronary angiography were divided into the CAD group (n=41) and control group (without CAD;n=15). CAD was defined as 75% occlusion in 1 major coronary arteries. Serum DHEA-S,lipid,and plasma glucose levels were determined after a 12-h fast. Coronary artery stenosis severity was estimated using the Gensini score. Results:DHEA-S levels were significantly lower in the CAD group than in the control group;however, other clinical parameters showed no difference between the groups. An age-adjusted multiple regression analysis revealed that DHEA-S-dependent determinants were significantly correlated with the Gensini score(β=-0.291,p<0.05), but not with other clinical parameters. Conclusions:Middle-aged and elderly men with CAD may have lower serum DHEA-S levels than age-matched men without CAD,and serum DHEA-S levels may negatively correlate with coronary artery stenosis severity in all men, suggesting a cardioprotective effect of DHEA-S.

Correlation between Serum Dehydroepiandrosterone Sulfate and Coronary Artery Disease in Middle-Aged and Elderly Men