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We describe a patient with biphenotypic acute leukemia (BAL) with T-lymphoid lineage and myeloid lineage differentiation[BAL (T/M)]. Cytogenetic analysis revealed complex chromosomal abnormalities, including der(2)t(2;11)(p21;q23). Neither leukemia cells nor T-cell receptor gene rearrangements were detected in the bone marrow samples after four courses of high dose cytosine arabinoside regimen. However, der(2)t(2;11)(p21;q23) anomaly persisted in most of metaphases. Fluorescence in situ hybridization(FISH)analysis with a probe for MLL did not detect the split signal. Forty-five cases of hematological disorder with t(2;11)(p21;q23) abnormality have been previously reported. The majority of such cases have been classified as myelodysplastic syndrome(MDS)or acute myeloid leukemia (AML). This is the first case BAL (T/M) associated with a t(2;11)(p21;q23) anomaly.(Kitakanto Med J 2012;62:287~290)

Der(2)t(2 ; 11)(p21 ; q23), a Variant form of t(2 ; 11), in Biphenotypic Acute Leukemia with T Lymphoid Lineage and Myeloid Lineage Differentiation