English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Preoperative molecular imaging is paramount to direct surgery in primary hyperparathyroidism (pHPT). We investigated the diagnostic performance of 18 F-fluorocholine ( 18 F-FCH) PET/CT compared with 11 C-methionine ( 11 C-MET) PET/CT for localization of hyperfunctioning parathyroid tissue in patients with pHPT and negative or inconclusive 99m Tc-sestaMIBI ( 99m Tc-MIBI) SPECT findings. Methods: Fifty-eight patients with biochemical evidence of pHPT and negative or inconclusive 99m Tc-MIBI SPECT findings were referred for presurgical detection and localization of hyperfunctioning parathyroid tissue by 11 C-MET and 18 F-FCH PET/CT. The PET/CT results were classified into 3 categories (positive, inconclusive, or negative) based on the nodular aspect of tracer uptake and the visualization of corresponding nodules on CT. The PET/CT results were correlated with the surgical and histopathologic findings, which were used as the gold standard. Results: Fifty-three patients were included for analysis. 18 F-FCH PET/CT was positive in 39 patients (74%), inconclusive in 5 (9%), and negative in 9 (17%), compared with 25 (47%), 12 (23%), and 16 (30%), respectively, for 11 C-MET PET/CT. 18 F-FCH localized 11 additional foci (6 positive and 5 inconclusive), compared with 11 C-MET. Twenty-six patients (sex ratio, 10/16 M/F) underwent surgery, with resection of 31 lesions (22 adenomas, 6 hyperplastic glands, and 3 carcinomas) and 1 normal gland. At follow-up, 21 patients (81%) were considered cured after surgery, whereas 3 patients (12%) had persistence of hypercalcemia. With inconclusive cases being considered negative, 18 F-FCH PET/CT correctly localized 26 lesions in 24 of 26 patients (92%), compared with 16 lesions in 15 of 26 patients (58%) localized by 11 C-MET PET/CT. Per-patient-based sensitivity and positive predictive value were 96% and 96%, respectively, for 18 F-FCH and 60% and 94%, respectively, for 11 C-MET ( P &lt; 0.0001). Per-lesion-based sensitivity and positive predictive value were 84% and 90%, respectively, for 18 F-FCH and 52% and 94%, respectively, for 11 C-MET ( P &lt; 0.0001). Conclusion: In the presence of biochemical evidence of pHPT with negative or inconclusive 99m Tc-MIBI SPECT findings, 18 F-FCH PET/CT performs better than 11 C-MET PET/CT for the detection of pathologic parathyroid tissue, allowing localization of parathyroid adenoma or hyperplasia in 96% of patients.

the journal of nuclear medicine

<sup>18</sup>F-fluorocholine PET/CT is more sensitive than <sup>11</sup>C-methionine PET/CT for the localization of hyperfunctioning parathyroid tissue in primary hyperparathyroidism

18F-fluorocholine PET/CT is more sensitive than 11C-methionine PET/CT for the localization of hyperfunctioning parathyroid tissue in primary hyperparathyroidism

¹⁸F-fluorocholine PET/CT is more sensitive than ¹¹C-methionine PET/CT for the localization of hyperfunctioning parathyroid tissue in primary hyperparathyroidism