English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Preoperative localization of pathologic parathyroids is crucial for minimally invasive treatment of primary hyperparathyroidism (PHPT). This study compared contrast-enhanced 18 F-fluorocholine PET/CT, cervical ultrasonography (CU), and conventional scintigraphic imaging modalities (MIBI scintigraphy, consisting of 99m Tc-sestamibi/ 123 I-sodium iodide SPECT/CT, 99m Tc-sestamibi/ 123 I-sodium iodide planar subtraction imaging, and 99m Tc-sestamibi planar dual-phase imaging), combined and individually, for preoperative localization of hyperfunctional parathyroids in PHPT. The gold standard was histologic examination. Methods: Data from consecutive patients with clinically suspected PHPT were retrospectively collected. All 3 imaging modalities were systematically performed. The ability of 18 F-fluorocholine PET/CT, CU, and MIBI scintigraphy to identify a hyperfunctional parathyroid and specify the side or identify an ectopic location was noted. Patients underwent surgical exploration if at least 1 examination was positive. The findings of CU + MIBI scintigraphy combined were considered positive if CU and MIBI scintigraphy separately showed a hyperfunctional parathyroid gland on the same side or in the same ectopic location; any findings other than these were considered negative. The composite judgment criterion for pathologic parathyroid was a combination of histologic analysis and normalization of parathyroid hormone and calcium levels. Results: In total, 149 pathologic parathyroids were found in 143 of the 144 included patients. 18 F-fluorocholine PET/CT diagnosed 148 of 149 pathologic parathyroids. Only 4 false-positives and 1 false-negative were found. The 18 F-fluorocholine PET/CT sensitivity of 99.3% was superior to that of CU, at 75.2% ( P &lt; 0.0001); MIBI scintigraphy, at 65.1% ( P &lt; 0.0001); and CU + MIBI scintigraphy, at 89.9%, ( P = 0.0009). Five of the 5 ectopic locations were diagnosed by 18 F-fluorocholine PET/CT, 2 of the 5 by MIBI scintigraphy, and none by CU. Accuracy was better for 18 F-fluorocholine PET/CT, at 98%, than for CU, at 84% ( P &lt; 0.0001); MIBI scintigraphy, at 81% ( P &lt; 0.0001); or CU + MIBI scintigraphy, at 91% ( P &lt; 0.0001). Among the 72 (50%) patients who had a negative CU + MIBI scintigraphy result, 18 F-fluorocholine PET/CT correctly identified hyperfunctional thyroids in 70 (97.2%). Average uptake in the 18 F-fluorocholine PET/CT hyperfunctional parathyroid was higher than that in the adjacent thyroid (SUV max adjusted for lean body mass, 6.45 vs. 2.15) ( P &lt; 0.0001). Conclusion: The accuracy of 18 F-fluorocholine PET/CT is higher than that of CU and MIBI scintigraphy for localization of hyperfunctional parathyroids, justifying the systematic use of 18 F-fluorocholine PET/CT as the first-line method for PHPT diagnosis.

the journal of nuclear medicine

Diagnostic Performance of Cervical Ultrasound, <sup>99m</sup>Tc-Sestamibi Scintigraphy, and Contrast-Enhanced <sup>18</sup>F-Fluorocholine PET in Primary Hyperparathyroidism

Diagnostic Performance of Cervical Ultrasound, 99mTc-Sestamibi Scintigraphy, and Contrast-Enhanced 18F-Fluorocholine PET in Primary Hyperparathyroidism

Diagnostic Performance of Cervical Ultrasound, ^99mTc-Sestamibi Scintigraphy, and Contrast-Enhanced ¹⁸F-Fluorocholine PET in Primary Hyperparathyroidism