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We sought to evaluate the performance of 68 Ga-DOTA-FAPI-04 (  68  Ga-FAPI) PET/MR for the diagnosis of primary tumor and metastatic lesions in patients with gastric carcinomas and to compare the results with those of 18 F-FDG PET/CT. Methods: Twenty patients with histologically proven gastric carcinomas were recruited, and each patient underwent both 18 F-FDG PET/CT and  68  Ga-FAPI PET/MR. A visual scoring system was established to compare the detectability of primary tumors and metastases in different organs or regions (the peritoneum, abdominal lymph nodes, supradiaphragmatic lymph nodes, liver, ovary, bone, and other tissues). The original SUV max and normalized SUV max (calculated by dividing a lesion's original SUV max with the SUV mean of the descending aorta) of selected lesions on both 18 F-FDG PET/CT and 68 Ga-FAPI PET/MR were measured. Original/normalized SUV max-FAPI and SUV max-FDG were compared for patient-based (including a single lesion with the highest activity uptake in each organ/region) and lesion-based (including all lesions [≤5] or the 5 lesions with highest activity [&gt;5]) analyses, respectively. Results: The 20 recruited patients (median age: 56.0 y; range: 29-70 y) included 9 men and 11 women, 14 patients for initial staging and 6 for recurrence detection. 68 Ga-FAPI PET was superior to 18 F-FDG PET for primary tumor detection (100.00% [14/14] vs. 71.43% [10/14]; P  = 0.034), and the former had higher tracer uptake levels ( P &lt; 0.05). 68 Ga-FAPI PET was superior to 18 F-FDG PET in both patient-based and lesion-based evaluation except for the metastatic lesions in supradiaphragmatic lymph nodes and ovaries. Additionally, multiple sequences of MR images were beneficial for the interpretation of hepatic metastases in 3 patients, uterine and rectal metastases in 1 patient, ovarian lesions in 7 patients, and osseous metastases in 2 patients. Conclusion:  68 Ga-FAPI PET/MR outperformed 18 F-FDG PET/CT in visualizing the primary and most metastatic lesions of gastric cancer and might be a promising method, with the potential of replacing 18 F-FDG PET/CT.

68Ga-DOTA-FAPI-04 PET/MR in the Evaluation of Gastric Carcinomas: Comparison with 18F-FDG PET/CT

⁶⁸Ga-DOTA-FAPI-04 PET/MR in the Evaluation of Gastric Carcinomas: Comparison with ¹⁸F-FDG PET/CT