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6″- 18 F-fluoromaltotriose is a PET tracer that can potentially be used to image and localize most bacterial infections, much like 18 F-FDG has been used to image and localize most cancers. However, unlike 18 F-FDG, 6″- 18 F-fluoromaltotriose is not taken up by inflammatory lesions and appears to be specific to bacterial infections by targeting the maltodextrin transporter that is expressed in gram-positive and gram-negative strains of bacteria. Methods: 6″- 18 F-fluoromaltotriose was synthesized with high radiochemical purity and evaluated in several clinically relevant bacterial strains in cultures and in living mice. Results: 6″- 18 F-fluoromaltotriose was taken up in both gram-positive and gram-negative bacterial strains. 6″- 18 F-fluoromaltotriose was also able to detect Pseudomonas aeruginosa in a clinically relevant mouse model of wound infection. The utility of 6″- 18 F-fluoromaltotriose to help monitor antibiotic therapies was also evaluated in rats. Conclusion: 6″- 18 F-fluoromaltotriose is a promising new tracer that has significant diagnostic utility, with the potential to change the clinical management of patients with infectious diseases of bacterial origin.

the journal of nuclear medicine

Specific Imaging of Bacterial Infection Using 6″-<sup>18</sup>F-Fluoromaltotriose: A Second-Generation PET Tracer Targeting the Maltodextrin Transporter in Bacteria

Specific Imaging of Bacterial Infection Using 6″-18F-Fluoromaltotriose: A Second-Generation PET Tracer Targeting the Maltodextrin Transporter in Bacteria

Specific Imaging of Bacterial Infection Using 6″-¹⁸F-Fluoromaltotriose: A Second-Generation PET Tracer Targeting the Maltodextrin Transporter in Bacteria