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The methylguanidine derivative 11 C-GMOM ( 11 C-labeled N -(2-chloro-3-thiomethylphenyl)- N '-(3-methoxyphenyl)- N '-methylguanidine) has been used successfully to quantify N -methyl-d-aspartate (NMDA) receptor binding in humans. The purpose of the present study was to estimate the 11 C-GMOM radiation dose in healthy humans. Methods: After 11 C-GMOM injection, 3 female and 2 male subjects underwent 10 consecutive whole-body PET scans in approximately 77 min. Seven source organs were defined manually, scaled to a sex-specific reference, and residence times were calculated for input into OLINDA/EXM software. Accepted tissue-weighting factors were used to calculate the effective dose. Results: The mean absorbed radiation doses in source organs ranged from 7.7 μGy·MBq -1 in the brain to 12.7 μGy·MBq -1 in the spleen. The effective dose (±SD) was 4.5 ± 0.5 μSv·MBq -1  Conclusion: The effective dose of 11 C-GMOM is at the lower end of the range seen for other 11 C-labeled ligands, allowing for serial PET scanning in a single subject.

Human Dosimetry of the N-Methyl-d-Aspartate Receptor Ligand 11C-GMOM