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We recently showed the high target specificity and favorable imaging properties of 64Cu and Al18F PET probes for noninvasive imaging of thrombosis. Here, our aim was to evaluate new derivatives labeled with either with 68Ga, 111In, or 99mTc as thrombus imaging agents for PET and SPECT. In this study, the feasibility and potential of these probes for thrombus imaging was assessed in detail in 2 animal models of arterial thrombosis. The specificity of the probes was further evaluated using a triple-isotope approach with multimodal SPECT/PET/CT imaging.

the journal of nuclear medicine

Multimodal Molecular Imaging Reveals High Target Uptake and Specificity of <sup>111</sup>In- and <sup>68</sup>Ga-Labeled Fibrin-Binding Probes for Thrombus Detection in Rats

Multimodal Molecular Imaging Reveals High Target Uptake and Specificity of 111In- and 68Ga-Labeled Fibrin-Binding Probes for Thrombus Detection in Rats

Multimodal Molecular Imaging Reveals High Target Uptake and Specificity of ¹¹¹In- and ⁶⁸Ga-Labeled Fibrin-Binding Probes for Thrombus Detection in Rats