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Melanoma is a malignant tumor derived from epidermal melanocytes, and it is known for its aggressiveness, therapeutic resistance, and predisposition for late metastasis. Very late antigen-4 (VLA-4; also called integrin α4β1) is a transmembrane noncovalent heterodimer overexpressed in melanoma tumors that plays an important role in tumor growth, angiogenesis, and metastasis by promoting adhesion and migration of cancer cells. In this study, we evaluated 2 conjugates of a high-affinity VLA-4 peptidomimetic ligand, LLP2A, for PET/CT imaging in a subcutaneous and metastatic melanoma tumor.

PET Imaging of Very Late Antigen-4 in Melanoma: Comparison of68Ga- and64Cu-Labeled NODAGA and CB-TE1A1P-LLP2A Conjugates

PET Imaging of Very Late Antigen-4 in Melanoma: Comparison of⁶⁸Ga- and⁶⁴Cu-Labeled NODAGA and CB-TE1A1P-LLP2A Conjugates