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Non-small cell lung cancer (NSCLC) is a highly morbid and mortal cancer type that is difficult to eradicate using conventional chemotherapy and radiotherapy. Little is known about whether radionuclide-based pharmaceuticals can be used for treating NSCLC. Here we embedded the therapeutic radionuclide (188)Re in PEGylated (PEG is polyethylene glycol) liposomes and investigated the biodistribution, pharmacokinetics, and therapeutic efficacy of this nanoradiopharmaceutical on NSCLC using a xenograft lung tumor model and the reporter gene imaging techniques.

the journal of nuclear medicine

Evaluation of the Therapeutic and Diagnostic Effects of PEGylated Liposome–Embedded <sup>188</sup>Re on Human Non–Small Cell Lung Cancer Using an Orthotopic Small-Animal Model

Evaluation of the Therapeutic and Diagnostic Effects of PEGylated Liposome–Embedded 188Re on Human Non–Small Cell Lung Cancer Using an Orthotopic Small-Animal Model

Evaluation of the Therapeutic and Diagnostic Effects of PEGylated Liposome–Embedded ¹⁸⁸Re on Human Non–Small Cell Lung Cancer Using an Orthotopic Small-Animal Model