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Soluble tumor necrosis factor (TNF) receptor-2 (TNFR2) and interleukin-1 receptor antagonist (IL-1ra) were fused to the Fc portion of IgG1 using recombinant DNA technology. The resulting dual-domain cytokine ligand, TNFR2-Fc-IL-1ra, specifically binds to TNF and to the type I IL-1 receptor (IL-1RI). This study was designed to characterize the kinetic profile of (99m)Tc-labeled TNFR2-Fc-IL-1ra (TFI) for imaging inflammatory response in an ischemic-reperfused (IR) rat heart model.

SPECT Imaging of Inflammatory Response in Ischemic–Reperfused Rat Hearts Using a 99mTc-Labeled Dual-Domain Cytokine Ligand

SPECT Imaging of Inflammatory Response in Ischemic–Reperfused Rat Hearts Using a ^99mTc-Labeled Dual-Domain Cytokine Ligand