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The linear correlation between (11)C-methionine PET and tumor cell density is not well conserved at the tumor border in glioma. A novel imaging analysis method, voxelwise (18)F-FDG-(11)C-methionine PET decoupling analysis (decoupling score), was evaluated to determine whether it could be used to quantitatively assess glioma cell infiltration in MRI-nonenhancing T2 hyperintense lesions.

A Novel PET Index, 18F-FDG–11C-Methionine Uptake Decoupling Score, Reflects Glioma Cell Infiltration

A Novel PET Index, ¹⁸F-FDG–¹¹C-Methionine Uptake Decoupling Score, Reflects Glioma Cell Infiltration