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The opioid and serotonergic systems are closely involved in pain processing and mood disorders. The aim of this study was to assess the influence of systemic morphine on cerebral serotonin 2A receptor (5-HT(2A)) binding in dogs using SPECT with the 5-HT(2A) radioligand (123)I-5I-R91150.

The Influence of Morphine on Cerebral 5-HT2A Availability in Dogs: a SPECT Study

The Influence of Morphine on Cerebral 5-HT_2A Availability in Dogs: a SPECT Study