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(18)F-fluoromisonidazole PET, a noninvasive means of identifying hypoxia in tumors, has been widely applied but with mixed results, raising concerns about its accuracy. The objective of this study was to determine whether kinetic analysis of dynamic (18)F-fluoromisonidazole data provides better discrimination of tumor hypoxia than methods based on a simple tissue-to-plasma ratio.

the journal of nuclear medicine

Image-Guided Po<sub>2</sub> Probe Measurements Correlated with Parametric Images Derived from <sup>18</sup>F-Fluoromisonidazole Small-Animal PET Data in Rats

Image-Guided Po2 Probe Measurements Correlated with Parametric Images Derived from 18F-Fluoromisonidazole Small-Animal PET Data in Rats

Image-Guided Po₂ Probe Measurements Correlated with Parametric Images Derived from ¹⁸F-Fluoromisonidazole Small-Animal PET Data in Rats