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Separate measurements of B(max), the density of available receptors, and K(D), the equilibrium dissociation constant in the human brain, with PET have contributed to our understanding of neuropsychiatric disorders, especially with respect to the dopamine D(2)/D(3) receptor system. However, existing methods have limited applications to the whole striatum, putamen, or caudate nucleus. Improved methods are required to examine B(max) and K(D) in detailed functional striatal subdivisions that are becoming widely used.

the journal of nuclear medicine

Dissociative Changes in the Bmax and KD of Dopamine D2/D3 Receptors with Aging Observed in Functional Subdivisions of the Striatum: A Revisit with an Improved Data Analysis Method