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PET of amino acid transport and metabolism may be more accurate than conventional neuroimaging in differentiating recurrent gliomas from radiation-induced tissue changes. α-(11)C-methyl-l-tryptophan ((11)C-AMT) is an amino acid PET tracer that is not incorporated into proteins but accumulates in gliomas, mainly because of tumoral transport and metabolism via the immunomodulatory kynurenine pathway. The aim of this study was to evaluate the usefulness of (11)C-AMT PET supplemented by tracer kinetic analysis for distinguishing recurrent gliomas from radiation injury.

Accurate Differentiation of Recurrent Gliomas from Radiation Injury by Kinetic Analysis of α-11C-Methyl-l-Tryptophan PET

Accurate Differentiation of Recurrent Gliomas from Radiation Injury by Kinetic Analysis of α-¹¹C-Methyl-l-Tryptophan PET