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Excretion of copper into bile requires the copper transporter Atp7b, which is deficient in Wilson disease. We hypothesized that a radiocopper-histidine complex would be effective for diagnosing Wilson disease by molecular imaging and tested this hypothesis in the Long-Evans cinnamon (LEC) rat model with Atp7b deficiency.

PET with 64Cu–Histidine for Noninvasive Diagnosis of Biliary Copper Excretion in Long–Evans Cinnamon Rat Model of Wilson Disease

PET with ⁶⁴Cu–Histidine for Noninvasive Diagnosis of Biliary Copper Excretion in Long–Evans Cinnamon Rat Model of Wilson Disease