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Nitric oxide (NO), the end product of the inducible form of NO synthase (iNOS), is an important mediator of a variety of inflammatory diseases. Therefore, a radiolabeled iNOS radiopharmaceutical for assessing iNOS protein concentration as a marker for its activity would be of value to the study and treatment of NO-related diseases. We recently synthesized an (18)F-radiolabeled analog of the reversible NOS inhibitor, 2-amino-4-methylpyridine ((18)F-NOS), and confirmed its utility in a murine model of lung inflammation. To determine its potential for use in humans, we measured (18)F-NOS myocardial activity in patients after orthotopic heart transplantation (OHT) and correlated it with pathologic allograft rejection, tissue iNOS levels, and calculated human radiation dosimetry.

Feasibility and Dosimetry Studies for 18F-NOS as a Potential PET Radiopharmaceutical for Inducible Nitric Oxide Synthase in Humans

Feasibility and Dosimetry Studies for ¹⁸F-NOS as a Potential PET Radiopharmaceutical for Inducible Nitric Oxide Synthase in Humans