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Activation of adenosine A(1) receptors (A(1)R) in the brain causes sedation, reduces anxiety, inhibits seizures, and promotes neuroprotection. Cerebral A(1)R can be visualized using 8-dicyclopropylmethyl-1-(11)C-methyl-3-propyl-xanthine ((11)C-MPDX) and PET. This study aims to test whether (11)C-MPDX can be used for quantitative studies of cerebral A(1)R in rodents.

Small-Animal PET Study of Adenosine A1 Receptors in Rat Brain: Blocking Receptors and Raising Extracellular Adenosine

Small-Animal PET Study of Adenosine A₁ Receptors in Rat Brain: Blocking Receptors and Raising Extracellular Adenosine