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Predicting biologic response after incorporation of radioactivity largely relies on calculating the absorbed dose. Traditionally, dosimetry has been performed using the mean absorbed dose at the organ level (1) and, more recently, at the suborgan and voxel levels (2). However, even if radioactivity appears to be homogeneous at the voxel level, radiopharmaceuticals do not distribute uniformly at the cellular level (3), either among different cells or among different subcellular compartments (4). This heterogeneous distribution at the cellular level can cause a wide range of

Lognormal Distribution of Cellular Uptake of Radiopharmaceuticals: Implications for Biologic Response in Cancer Treatment