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In peptide receptor radionuclide therapy of neuroendocrine tumors, improvements have been made by increasing the affinity for receptors and by protecting critical organs (e.g., kidneys). However, tumor parameters involved in radiopeptide uptake are still under investigation. Interferon-α (IFNα) is used as biotherapy for neuroendocrine tumors. Several mechanisms of action are described, but the potential effect of IFNα on tumor uptake of labeled peptide has not been studied in vivo yet.

Effect of Interferon-α Treatment on [68Ga-DOTA,Tyr3,Thre8]Octreotide Uptake in CA20948 Tumors: A Small-Animal PET Study

Effect of Interferon-α Treatment on [⁶⁸Ga-DOTA,Tyr3,Thre8]Octreotide Uptake in CA20948 Tumors: A Small-Animal PET Study