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High kidney radiation doses during clinical peptide receptor radionuclide therapy (PRRT) with β-particle-emitting radiolabeled somatostatin analogs will lead to renal failure several months after treatment, urging the coinfusion of the cationic amino acids lysine and arginine to reduce the renal radiation dose. In rat PRRT studies, renal protection by the coadministration of lysine was confirmed by histologic examination of kidney specimens indicating nephrotoxicity. In the current study, we investigated dedicated small-animal SPECT/CT renal imaging in rats to monitor renal function in vivo during follow-up of PRRT, with and without lysine.

the journal of nuclear medicine

Dynamic and Static Small-Animal SPECT in Rats for Monitoring Renal Function After <sup>177</sup>Lu-Labeled Tyr<sup>3</sup>-Octreotate Radionuclide Therapy

Dynamic and Static Small-Animal SPECT in Rats for Monitoring Renal Function After 177Lu-Labeled Tyr3-Octreotate Radionuclide Therapy

Dynamic and Static Small-Animal SPECT in Rats for Monitoring Renal Function After ¹⁷⁷Lu-Labeled Tyr³-Octreotate Radionuclide Therapy