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The most accurate way to estimate the glucose metabolic rate (or its influx constant) from (18)F-FDG PET is to perform a full kinetic analysis (or its simplified Patlak version), requiring dynamic imaging and the knowledge of arterial activity as a function of time. To avoid invasive arterial blood sampling, a simplified kinetic analysis (SKA) has been proposed, based on blood curves measured from a control group. Here, we extend the SKA by allowing for a greater variety of arterial input function (A(t)) curves among patients than in the original SKA and by accounting for unmetabolized (18)F-FDG in the tumor.

Searching for Alternatives to Full Kinetic Analysis in 18F-FDG PET: An Extension of the Simplified Kinetic Analysis Method

Searching for Alternatives to Full Kinetic Analysis in ¹⁸F-FDG PET: An Extension of the Simplified Kinetic Analysis Method