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Meta-iodobenzylguanidine (MIBG) labeled with (123)I or (131)I has been widely used for the diagnosis and radiotherapy of norepinephrine transporter (NET)-expressing tumors. However, (123)I/(131)I-MIBG has limitations for detecting small lesions because of its lower spatial resolution than PET tracers. In this study, meta-bromobenzylguanidine (MBBG) labeled with (76)Br (half-life, 16.1 h), an attractive positron emitter, was prepared and evaluated as a potential PET tracer for imaging NET-expressing tumors.

PET Imaging of Norepinephrine Transporter–Expressing Tumors Using 76Br-meta-Bromobenzylguanidine

PET Imaging of Norepinephrine Transporter–Expressing Tumors Using ⁷⁶Br-meta-Bromobenzylguanidine