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(111)In-nuclear localization sequence-trastuzumab is a radioimmunotherapeutic agent consisting of trastuzumab modified with NLS peptides (CGYGPKKKRKVGG) and labeled with the Auger electron emitter (111)In. Our objectives were to evaluate the tumor growth-inhibitory properties and normal-tissue toxicity of (111)In-NLS-trastuzumab in mice after intraperitoneal administration.

the journal of nuclear medicine

Antitumor Effects and Normal-Tissue Toxicity of <sup>111</sup>In-Nuclear Localization Sequence-Trastuzumab in Athymic Mice Bearing <i>HER</i>-Positive Human Breast Cancer Xenografts

Antitumor Effects and Normal-Tissue Toxicity of 111In-Nuclear Localization Sequence-Trastuzumab in Athymic Mice Bearing HER-Positive Human Breast Cancer Xenografts

Antitumor Effects and Normal-Tissue Toxicity of ¹¹¹In-Nuclear Localization Sequence-Trastuzumab in Athymic Mice Bearing HER-Positive Human Breast Cancer Xenografts