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cation, and standard operating procedure protocols. Consequently, the solutions have to be prepared from highpurity batches, have to be kept in closed vials, and have to be refrigerated or stored at 220 C for a limited time only. If not, the sterility of the Millipore water and the saline solutions is not guaranteed, the composition of the acetone/HCl mixtures will change because of the low boiling points of the compounds, and the acetone in acidic media will undergo an aldol addition reaction forming 4-methyl-3-penten-2-on. We appreciate the effort of Petrik et al. to ‘‘finally’’ identify this well-known product, confirming the standard education of chemistry students (6). If it was the intention of the present letter to the editor to reflect the relevancy of creating and following standard operating procedures for the synthesis of radiopharmaceuticals, we completely agree. Regarding the nontoxic compound 4-methyl-3penten-2-on, Petrik et al. correctly state that its formation is negligible if acetone/HCl mixtures are stored with protection from light at 220 C or if freshly prepared mixtures are used.

Side Effects Profile in Humans of 11C-(+)-PHNO, a Dopamine D2/3 Agonist Ligand for PET

Side Effects Profile in Humans of ¹¹C-(+)-PHNO, a Dopamine D_2/3 Agonist Ligand for PET