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(18)F-4-(2'-methoxyphenyl)-1-[2'-(N-2-pyridinyl)-p-fluorobenzamido]-ethyl-piperazine ((18)F-MPPF) PET has proved to be a sensitive technique in the presurgical evaluation of patients with drug-resistant temporal lobe epilepsy (TLE), but a significant proportion of visually detected abnormalities failed to be detected by standard statistical parametric mapping (SPM) analysis. This study aimed at describing a voxel-based method for computing interhemispheric asymmetric index (AI) using statistical software and applying and validating the clinical relevance of this method for analyzing asymmetries of (18)F-MPPF PET images in patients with drug-resistant TLE.

the journal of nuclear medicine

Voxel-Based Analysis of Asymmetry Index Maps Increases the Specificity of <sup>18</sup>F-MPPF PET Abnormalities for Localizing the Epileptogenic Zone in Temporal Lobe Epilepsies

Voxel-Based Analysis of Asymmetry Index Maps Increases the Specificity of 18F-MPPF PET Abnormalities for Localizing the Epileptogenic Zone in Temporal Lobe Epilepsies

Voxel-Based Analysis of Asymmetry Index Maps Increases the Specificity of ¹⁸F-MPPF PET Abnormalities for Localizing the Epileptogenic Zone in Temporal Lobe Epilepsies