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PET scanners with an elongated axial field of view intended to increase overall system sensitivity, such as the high-resolution research tomograph (HRRT) scanner, have been reported to produce images with decreased signals in the brain stem and cerebellum. The cause of this negative bias of the images was analyzed, and the effects of an inaccurate linear attenuation coefficient (mu-value) of tissue and bones were separately examined.

Analysis of Biased PET Images Caused by Inaccurate Attenuation Coefficients