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Striatal dopamine D(2) receptor (D2R) PET has been proposed to differentiate between Parkinson disease (PD) and multiple-system atrophy with predominant parkinsonism (MSA-P). However, considerable overlap in striatal D(2) binding may exist between PD and MSA-P. It has been shown that imaging of neuronal activity, as determined by metabolism or perfusion, can also help distinguish PD from MSA-P. We investigated whether the differential diagnostic value of (11)C-raclopride PET could be improved by dynamic scan analysis combining D2R binding and regional tracer influx.

the journal of nuclear medicine

Combined Striatal Binding and Cerebral Influx Analysis of Dynamic <sup>11</sup>C-Raclopride PET Improves Early Differentiation Between Multiple-System Atrophy and Parkinson Disease

Combined Striatal Binding and Cerebral Influx Analysis of Dynamic 11C-Raclopride PET Improves Early Differentiation Between Multiple-System Atrophy and Parkinson Disease

Combined Striatal Binding and Cerebral Influx Analysis of Dynamic ¹¹C-Raclopride PET Improves Early Differentiation Between Multiple-System Atrophy and Parkinson Disease