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Selective internal radiation treatment (SIRT) via intrahepatic arterial administration of (90)Y microspheres is an effective therapeutic modality. The conventional and generally applied MIRD schema is based on the premise that the distribution of microspheres in the liver parenchyma is uniform. In reality, however, the distribution of the microspheres follows a distinct pattern, requiring that a model be developed to more appropriately estimate radiation absorbed doses to the different structural/functional elements of the hepatic microanatomy.

Hepatic Structural Dosimetry in 90Y Microsphere Treatment: A Monte Carlo Modeling Approach Based on Lobular Microanatomy

Hepatic Structural Dosimetry in ⁹⁰Y Microsphere Treatment: A Monte Carlo Modeling Approach Based on Lobular Microanatomy