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This article describes the evaluation of the radiopharmaceutical (64)Cu-CB-TE2A-c(RGDyK) ((64)Cu-RGD) as an imaging agent for osteolytic bone metastases and their associated inflammation by targeting of the alpha(v)beta(3) integrin on osteoclasts and the proinflammatory cells involved at the bone metastatic site.

Targeting the αvβ3 Integrin for Small-Animal PET/CT of Osteolytic Bone Metastases

Targeting the α_vβ₃ Integrin for Small-Animal PET/CT of Osteolytic Bone Metastases