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Reduced cerebral blood flow and cerebrovascular reactivity to acetazolamide have been used as predictors for subsequent ischemic stroke in patients with occlusive carotid artery diseases, called type 3 ischemia. However, recent studies have shown that reduced cerebrovascular reactivity to acetazolamide does not always represent elevated oxygen extraction fraction (OEF). The aim of this study was to establish the methodology to improve the validity of an acetazolamide test identifying elevated OEF.

the journal of nuclear medicine

Combination of a Mean Transit Time Measurement with an Acetazolamide Test Increases Predictive Power to Identify Elevated Oxygen Extraction Fraction in Occlusive Carotid Artery Diseases