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The chemokine stromal-derived factor-1alpha (SDF-1alpha, CXCL12) and its receptor CXCR4 are implicated as key mediators of hematopoietic stem cell retention, cancer metastasis, and HIV infection. Their role in myocardial infarction (MI) is not as well defined. The noninvasive in vivo quantitation of CXCR4 expression is central to understanding its importance in these diverse processes as well in the cardiac response to injury.

Quantitation of CXCR4 Expression in Myocardial Infarction Using 99mTc-Labeled SDF-1α

Quantitation of CXCR4 Expression in Myocardial Infarction Using ^99mTc-Labeled SDF-1α