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PET molecular imaging of 15O-labeled water is the gold standard for measuring blood flow in humans. However, this requires an on-site cyclotron to produce the short-lived 15O tracer, which is cost-prohibitive for most clinical PET centers. The purpose of this study was to determine if the early uptake of 18F-FDG could be used to measure regional blood flow in tumors in the absence of 15O-water.

the journal of nuclear medicine

Tumor Blood Flow Measured by PET Dynamic Imaging of First-Pass <sup>18</sup>F-FDG Uptake: A Comparison with <sup>15</sup>O-Labeled Water-Measured Blood Flow

Tumor Blood Flow Measured by PET Dynamic Imaging of First-Pass 18F-FDG Uptake: A Comparison with 15O-Labeled Water-Measured Blood Flow

Tumor Blood Flow Measured by PET Dynamic Imaging of First-Pass ¹⁸F-FDG Uptake: A Comparison with ¹⁵O-Labeled Water-Measured Blood Flow