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3'-Deoxy-3'-(18)F-fluorothymidine ((18)F-FLT), a partially metabolized thymidine analog, has been used in preclinical and clinical settings for the diagnostic evaluation and therapeutic monitoring of tumor proliferation status. We investigated the use of (18)F-FLT for detecting and characterizing genetically engineered mouse (GEM) high-grade gliomas and evaluating the pharmacokinetics in GEM gliomas and normal brain tissue. Our goal was to develop a robust and reproducible method of kinetic analysis for the quantitative evaluation of tumor proliferation.

the journal of nuclear medicine

Dynamic Small-Animal PET Imaging of Tumor Proliferation with 3′-Deoxy-3′-<sup>18</sup>F-Fluorothymidine in a Genetically Engineered Mouse Model of High-Grade Gliomas

Dynamic Small-Animal PET Imaging of Tumor Proliferation with 3′-Deoxy-3′-18F-Fluorothymidine in a Genetically Engineered Mouse Model of High-Grade Gliomas

Dynamic Small-Animal PET Imaging of Tumor Proliferation with 3′-Deoxy-3′-¹⁸F-Fluorothymidine in a Genetically Engineered Mouse Model of High-Grade Gliomas