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Quantitative PET with (15)O provides absolute values for cerebral blood flow (CBF), cerebral blood volume (CBV), cerebral metabolic rate of oxygen (CMRO(2)), and oxygen extraction fraction (OEF), which are used for assessment of brain pathophysiology. Absolute quantification relies on physically accurate measurement, which, thus far, has been achieved by 2-dimensional PET (2D PET), the current gold standard for measurement of CBF and oxygen metabolism. We investigated whether quantitative (15)O study with 3-dimensional PET (3D PET) shows the same degree of accuracy as 2D PET.

Quantification of Cerebral Blood Flow and Oxygen Metabolism with 3-Dimensional PET and 15O: Validation by Comparison with 2-Dimensional PET

Quantification of Cerebral Blood Flow and Oxygen Metabolism with 3-Dimensional PET and ¹⁵O: Validation by Comparison with 2-Dimensional PET