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The exposure of anionic phospholipids is a near-universal molecular signature for cell death. Based on our prior finding that the (99m)Tc-labeled C2A domain of synaptotagmin I accumulates intensely in the area at risk, this study quantitatively characterized the temporal and spatial distribution of the radiotracer in a rat model of myocardial ischemia and reperfusion.

Imaging Acute Cardiac Cell Death: Temporal and Spatial Distribution of 99mTc-Labeled C2A in the Area at Risk After Myocardial Ischemia and Reperfusion